![]() Effects of Prenatal Maternal Depression and Antidepressant Exposures on Offspring Neurodevelopmental Trajectories: A Birth Cohort Studyĭescription: This study addresses the potential effects of antidepressant medication use during pregnancy on infant neurodevelopment. Although previous work had suggested there may be increased psychiatric problems in adolescents who were exposed to SSRIs, this study will be able to confirm these findings definitively using three different populations.ģ. This is an important public health question, as antidepressant use in pregnancy has been increasing. Role: Co-Investigator (Principal Investigator: Ardesheer Talati, PhD)ĭescription: The overall goal of this three-year project is to test the long-term effects of maternal antidepressant use on offspring mental health in adolescence. A Multi-Cohort Assessment of Gestational SSRI Exposure on Long-Term Psychiatric Outcomes Serotonin and the Modulation of Brain Developmentĭescription: This project studies the mechanisms underlying the impact of early SSRI exposure on adult emotional function in mice.Ģ. Additionally, his group has developed a mouse model of epigenetic effects of paternal age on behavior and brain function.ġ. His group also has an active program examining the role of the neurotransmitter serotonin on the development of brain circuits that modulate affective and anxiety states. These studies have demonstrated an important role for cortical influence on behaviors related to schizophrenia and anxiety. Gingrich is pursuing several lines of research related to the role of serotonin-signaling in the cortex. ![]() His group exploits the ability to genetically modify mice-either to mimic known human susceptibility factors or to use conditional gene modifications-to further investigate their hypotheses regarding circuitry and physiology. ![]() Their goal is to understand how genetic and epigenetic factors affect behavior and intervening systems such as circuitry, anatomy, and physiology. Gingrich and his research group use a systems approach to better understand normal and abnormal brain function in particular, the mechanisms that underlie neuropsychiatric disorders such as schizophrenia, depression, and anxiety disorders. ![]()
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